Skip To Main Content
Simeon Babarinde on Muck Rack

Simeon Babarinde

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Simeon

Contact Simeon, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

|
By Kyong T. Fam, Pavan Kumar Chodisetti, Zifei Wang, Joshua A. Homer, Christopher J. Smedley, Seiya Kitamura, Benjamin A. Silva, Yijun Xiong, Althea Hansel-Harris, Matthew Holcomb, Simeon Babarinde, Adrianna M Turner, Daria Van Tyne, Ian Wilson, Stefano Forli, Benjamin Cravatt, Donghyun Park, Dennis W. Wolan, John E. Moses, Howard C. Hang
| Nature Verified
Abstract Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of healthcare-associated infections globally and demands new approaches for treatment. Here we show that genetic and pharmacological inactivation of a highly conserved NlpC/P60 peptidoglycan hydrolase, secreted antigen A (SagA), enhanced vancomycin susceptibility of VREfm ex vivo and in vivo. Notably, genetic deletion of sagA impaired VREfm peptidoglycan remodeling, growth and increased the activity of vancomycin.
Open in Who Shared Issue with article?
See all 1 articles