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Articles by Siming Li
Targeting inhibitory phagocytosis checkpoints in cancer immunotherapy: mechanisms, therapeutic strategies, and translational challenges
Abstract Tumors evade macrophage-mediated clearance through mechanistically distinct but functionally convergent anti-phagocytic pathways. This review examines canonical and emerging receptor–ligand “don’t eat me” axes, Siglec-dependent glyco-inhibitory checkpoints, and an emerging noncanonical glycocalyx barrier associated with sialylated CD43, linking these mechanisms to impaired macrophage recognition and activation, phagocytic synapse formation, and target-cell engulfment.
Optimal timing of surgery after conversion therapy for initially unresectable hepatocellular carcinoma: a multicenter study integrating major pathological response and treatment duration
Abstract Objective: The optimal timing of surgery after conversion therapy for initially unresectable hepatocellular carcinoma (uHCC) remains unclear. This study aimed to evaluate whether surgical timing can be optimized by integrating major pathological response (MPR), defined as residual viable tumor (RVT) ≤15%, with preoperative treatment duration.
Slow-water strategy for fracture-resistant hydrogels
Abstract Water in hydrogels has often been overlooked or deemed detrimental to the mechanical properties of hydrogels due to the plasticizing effect of water, which weakens interchain interactions and accelerates crack propagation. Here, we propose a slow-water strategy that imparts enhanced fracture resistance to hydrogels.
Hydrogel Adhesives Against Interfacial Mismatch Induced by Extreme Dryness via Water-State Reconstruction
Rongtai Wan and Yan Mu contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adfm76574-sup-0001-SuppMat.docx3.3 MB Supporting File 1: adfm76574-sup-0001-SuppMat.docx. adfm76574-sup-0002-VideoS1.mp45.8 MB Supporting File 2: adfm76574-sup-0002-VideoS1.mp4.
A phase II peri-operative study of pembrolizumab plus lenvatinib for mucosal melanoma
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Abstract Mucosal melanoma is an aggressive malignancy with limited neoadjuvant options. We conducted a single arm, phase II study of neoadjuvant pembrolizumab plus lenvatinib followed by surgery and adjuvant pembrolizumab in resectable mucosal melanoma (NCT04622566) along with exploratory biomarker analysis.
By Lili Mao, Yumei Lai, Hong Zheng, Ming Cui, Lifeng Li, Ziyi Liu, Hongyu Zhou, Linzi Sun, Caili Li, Xiaoting Wei, Xue Bai, Yan Kong, Chuanliang Cui, Zhihong Chi, Xinan Sheng, Bin Lian, Siming Li, Xieqiao Yan, Bixia Tang, Juan Li, Li Zhou Verified, Xuan Wang, Jun Guo, Jie Dai, Lu Si
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Nature
Verified
Enhancing flood peak simulation in data-scarce mountain river basins: the CRFMODEL framework
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Calandagan and Mickael Barzalona conquer the 45th Japan Cup in association with Longines - Longines - Media Center
The 45th edition of the Japan Cup in association with Longines was held at the Tokyo Racecourse on 30 November. As the Official Partner and Official Time Partner of this prestigious race, Longines continues to celebrate the achievements of the sport's top riders and horses in this demanding discipline, proudly timing the glorious victory of Calandagan ridden by Mickael Barzalona. The horse broke the course record with an outstanding run.
Longines and the Longines Global Champions Tour Announce Renewal of Long Term Partnership Through 2032
Longines and the Longines Global Champions Tour are pleased to announce the renewal of their long-standing partnership through 2032. This extension reaffirms Longines' position as the Title Partner and Official Timekeeper of the world-renowned show jumping circuit, continuing a collaboration that first began in 2012 and underscores the success of the collaboration and the growing popularity of the equestrian sport.
LONGINES celebrates Tom Wachman as Rising Star at FEI Awards 2025 in Hong Kong
Longines is proud to honour Irish show jumping athlete Tom Wachman with the Longines FEI Rising Star Award 2025. The 20-year-old rider received an elegant Longines timepiece at the FEI Awards Gala on November 7, held in Hong Kong following the 2025 FEI General Assembly. This recognition celebrates not only Tom's remarkable achievements but also Longines' enduring commitment to supporting the next generation of equestrian champions.
Opening of the FIS Alpine Ski World Cup 2025–2026 in Sölden - Longines - Media Center
The 2025–2026 FIS Alpine Ski World Cup has begun under the banner of precision and performance. As Official Partner and Official Timekeeper of the International Ski Federation (FIS), Longines continues its commitment to supporting all athletes on the world circuit. The new season kicked off on 25 and 26 October in Sölden, Austria, where the world's top skiers gathered for the first races of the World Cup on the Rettenbach glacier.
World's top riders shine at the 2025 LONGINES Equestrian Beijing Masters
From October 16th to 19th, the spotlight of the international equestrian community turned to the iconic Bird's Nest stadium in Beijing, China, where the prestigious LONGINES Equestrian Beijing Masters unfolded. As the Title Partner and Official Timekeeper, Longines reaffirmed its commitment to excellence in equestrian sport by timing the thrilling victory of German rider Daniel Deusser aboard Nand van 't Bergske, who triumphed in the LONGINES Grand Prix.
LONGINES celebrates the epic win of Daryz at the 2025 Qatar Prix de l'Arc de Triomphe - Longines - Media Center
The world's top horse-and-rider combinations continued to showcase their exploits on the racetrack at the 2025 Qatar Prix de l'Arc de Triomphe on October 5 at the ParisLongchamp racecourse. Longines was proud to time the stunning win of Daryz ridden by Mickael Barzalona in the prestigious Qatar Prix de l'Arc de Triomphe.
Great Britain claims championship glory at the LONGINES League of Nations™ Final in Barcelona
Barcelona's Real Club de Polo provided the stage for four days of extraordinary competition as the LONGINES League of Nations™ Final unfolded from 2 to 5 October, bringing the 2025 series to its thrilling conclusion. In its capacity as Official Partner, Official Timekeeper and Official Watch, Longines celebrated the triumph of Great Britain in the LONGINES League of Nations™ Final, marking a spectacular finish to another remarkable season of this elite championship.
The world's leading show jumping athletes return to Vienna for another thrilling chapter of the LONGINES Global Champions Tour
The magnificent Schönbrunn Palace welcomed the world's finest show jumping athletes from 26 to 28 September as the 2025 LONGINES Global Champions Tour made its highly anticipated stop in Vienna.
The Mediterranean coast welcomes equestrian excellence as the LONGINES League of Nations™ reaches its defining moment
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Elite riders converge for the CHIO Rotterdam and another prestigious leg of the Longines League of Nations™
Press release The Longines League of Nations™ continues its captivating journey across three continents, bringing together the world's finest riders in pursuit of equestrian excellence from February to October. The third leg, held in the heart of Rotterdam, Netherlands, from 19-22 June, witnessed the exceptional victory of the Netherlands in the Longines League of Nations™ in Rotterdam.
2025 Longines Global Champions Tour continues with spectacular competition in Paris
Press release The 2025 Longines Global Champions Tour in Paris delivered another chapter of equestrian excellence from 20 to 22 June, showcasing world-class show jumping in the magnificent setting of the French capital. As Title Partner, Official Timekeeper and Official Watch of the series, Longines recorded the outstanding victory of Gilles Thomas (Belgium) on Ermitage Kalone in the weekend's premier event, the Longines Global Champions Tour Grand Prix of Paris on Saturday, 21 June.
World-class horses and jockeys converge at Royal Ascot for five days of exceptional racing supported by Longines
The Swiss watchmaker Longines takes pride in celebrating Royal Ascot, held from 17th to 21st June, one of the world's most distinguished horseracing gatherings, renowned for its quintessential English elegance and sporting tradition. As Official Partner, Official Time Partner and Official Watch, Longines reinforces its enduring commitment to this remarkable event and the exceptional horses and jockeys who compete at the pinnacle of their discipline.
Longines Balve Optimum 2025: Longines’ Ambassador of Elegance, Sönke Rothenberger, wins the German Dressage Championship - Longines - Media Center
From June 12 to 15, 2025, Balve was once again the center of German equestrian sport. Against the impressive backdrop of Wocklum Castle, equestrian enthusiasts experienced thrilling competitions at the highest level. Longines’ Ambassador of Elegance, Sönke Rothenberger, secured the prestigious Longines Grand Optimum — and with it, the German Championship title in dressage.
Gezora and Christophe Soumillon: Champions of the 176th Prix de Diane Longines
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The Longines CSIO St. Gallen 2025 delivers world-class sport as Scott Brash clinches Grand Prix victory
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Longines times the 151st Kentucky Derby and Longines Kentucky Oaks
The 151st Longines Kentucky Oaks and Kentucky Derby, which took place from May 2nd to 3rd, concluded in spectacular fashion last weekend in Louisville, Kentucky (USA). As the Official Partner, Official Timekeeper and Official Watch of the Kentucky Derby, Longines played a vital role in timing the epic victory of Sovereignty in the event on Saturday.
Longines celebrates spectacular wins at the 2025 Dubai World Cup
The Dubai World Cup, which took place on April 5, saw the world’s finest horses and jockeys battling for glory on the track, marking the end of the Dubai World Cup Carnival. Meydan Racecourse provided a spectacular setting for two standout races: The Longines Dubai Sheema Classic and the prestigious Dubai World Cup Race. As the Official Partner, Official Timekeeper, and Official Watch of the event, Longines once again celebrated excellence in horse racing with the top talent.
Julien Epaillard claims victory at the Longines FEI Jumping World CupTM Final in Basel
The Longines FEI Jumping World CupTM Final, held from April 2nd to 6th in Basel, was an unforgettable showcase of elite showjumping, with the world’s top riders gathered for head-to-head battles. As the Title Partner, Official Timekeeper and Official watch of the event, Longines timed the brilliant victory of Julien Epaillard on Donatello d'Auge who claimed the coveted title in the Longines FEI Jumping World CupTM Final.
Famsin and fasting adaptation: A glucagon connection
Get full text access Log in, subscribe or purchase for full access. References 1. Long, A. ∙ Wang, Y. ∙ Guo, Y. ... A famsin-glucagon axis mediates glucose homeostasis Cell Metab. 2024; 37:629-639.e6 2. Tang, D. ∙ Tang, Q. ∙ Huang, W. ... Fasting: From Physiology to Pathology Adv. Sci. 2023; 10, e2204487 3. Ruppert, P.M.M. ∙ Kersten, S. Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting Trends Endocrinol. Metab. 2024; 35:107-124 4. Muller, T.D. ∙ Nogueiras, R. ∙ Andermann, M.L. ...
2025 Longines Global Champions Tour kicks off with electrifying competition
The 2025 Longines Global Champions Tour in Doha heralded the start of a new season of equestrian excellence at the breathtaking Longines Arena at Al Shaqab from 27 February to 1 March. As the Title Partner and Official timekeeper of the series, Longines timed the outstanding victory of Abdel Said (Belgium) on Bonne Amie in the weekend’s highlight trial - the Longines Global Champions Tour Grand Prix of Doha.
Elite riders return to Abu Dhabi for an exciting new season of the Longines League of Nations™ - Longines - Media Center
The Longines League of Nations™ is back for a thrilling new season, bringing together elite riders vying for victory across three continents from February to October. The kick-off leg, held in the heart of Abu Dhabi, UAE, from February 12th to 15th, saw the marvellous victory of Rolf-Göran Bengtsson (Sweden) in the Emirates Jumping Cup presented by Longines. On Saturday, Team Ireland made an early statement in the competition by winning the first leg of the 2025 Longines League of Nations™.
2024 Longines World Racing Awards celebrate excellence in horse racing - Longines - Media Center
On 21 January, Swiss watch brand Longines and the International Federation of Horseracing Authorities (IFHA) celebrated the diverse talents that contributed to the world of horse racing at the 2024 Longines World Racing Awards ceremony in London. City of Troy and Laurel River shared the 2024 Longines World’s Best Racehorse title, while the Juddmonte International Stakes (G1) was named the 2024 Longines World’s Best Horse Race.
French Rider Julien Epaillard takes spectacular win at the Longines CHI Classics Basel - Longines - Media Center
The equestrian world had geared up for a thrilling spectacle as the elite riders returned to Basel for the Longines CHI Classics Basel, held from January 8th to January 12th at St. Jakobshalle.
The 2024 Longines Hong Kong International Races
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James McDonald honoured as the 2024 Longines World’s Best Jockey - Longines - Media Center
With a string of successes achieved during his 2024 racing season, James McDonald was honoured as the 2024 Longines World’s Best Jockey on December 6 at the Longines Hong Kong International Races Gala Dinner.
Do Deuce dominates the 44th Japan Cup in association with Longines - Longines - Media Center
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Victor Bettendorf emerges victorious at the Longines Global Champions Tour Super Grand Prix in Riyadh
The world’s top riders battled for victory in the ultimate show jumping showdown in the Longines Global Champions Tour Super Grand Prix from November 20th to 23rd in Riyadh (Saudi Arabia). The winners of each LGCT Grand Prix event of the season won their golden ticket to this extraordinary four-day event and the ultimate battle was rounded off by the sensational victory of Victor Bettendorf (Luxembourg) on Foxy de la Roque.
Sierra Leone gallops to victory in the 41st Breeders' Cup World Championships
Widely known as thoroughbred racing's most prestigious international event of the year, the 41st edition of the Breeders' Cup World Championships took place on November 1 and 2 in Del Mar, California (US). Longines, the Official Partner and Official Timekeeper of the event, timed the sensational win of Sierra Leone ridden by Flavien Prat in the Longines Breeders' Cup Classic, further cementing the elite status of this annual series on the international stage.
Longines joins its Ski Athletes to kick off the FIS Alpine Ski World Cup 2024/2025 in Sölden - Longines - Media Center
Press release The world’s greatest skiers returned to Sölden (Austria) for the start of a brand-new Alpine Ski World Cup season. As the Official Partner and Official Timekeeper of the International Ski Federation (FIS), Longines was on the slopes with the world’s extraordinary alpine ski talents and timed their stunning performances.
Germany triumphs at the Longines League of Nations™ Final in Barcelona
Press release The elite riders in showjumping engaged in four days of intense competitions in the Longines League of Nations™ Final that took place from 3rd to 6th October at the Real Club de Polo de Barcelona in Barcelona, Spain. With its role as the Official Partner, Official Timekeeper and Official Watch, Longines celebrated the brilliant victory of Team Germany in the Longines League of Nations™ Final, ending the first season of the brand-new series in a blaze of glory. Media Download images
Local Weather and Global Climate Data-Driven Long-Term Runoff Forecasting Based on Local-Global-Temporal Attention Mechanisms and Graph Attention Networks
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Ines Joly brings home the Longines Global Champions Tour Grand Prix du Prince de Monaco title with a thrilling display - Longines - Media Center
Press release The world’s leading show jumping athletes continued to forge their own legacies at the Longines Global Champions Tour from July 4th to 6th in Monaco. As the Title Partner and Official Timekeeper of the series, Longines deepened its support for showjumping by timing the victory of Ines Joly (France) in the weekend’s highlight trial - the Longines Global Champions Tour Grand Prix du Prince de Monaco. Media Download images
Regé-Jean Page joins Longines for spectacular horseracing and elegance at Royal Ascot 2024 - Longines - Media Center
Press release Longines was proud to take part in five days of breathtaking horseracing from 18th to 22nd June at Royal Ascot as its Official Partner, Official Timekeeper, and Official Watch. At this year’s event, the Swiss watch brand was joined by its Ambassador of Elegance, Regé -Jean Page to celebrate excellence at this annual event characterized by its traditional English sartorial elegance. Media Download images
Longines Ambassador of Elegance Eddie Peng celebrates stellar victories of top equestrian talents at the Longines Global Champions Tour in Shanghai
Press release The Longines Global Champions Tour returned to Shanghai for the first time in four years for three days of adrenalin-filled competitions from May 3rd to 5th at the Shanghai Expo Park. As the Title Partner and Official Timekeeper of the series, Longines was joined this time by its Ambassador of Elegance Eddie Peng to support top equestrian talents at this highly anticipated event.
LONGINES CELEBRATES THE 150TH ANNIVERSARY OF THE KENTUCKY DERBY AND THE LONGINES KENTUCKY OAKS - Longines - Media Center
Press release This year marks the 150th anniversary of the prestigious Longines Kentucky Oaks and Kentucky Derby horse races that took place from the 3rd to the 4th of May in Louisville, Kentucky (USA). As the Official Timekeeper and Official Watch of the Kentucky Derby, Longines timed the victory of Mystik Dan in the 150th running of the event on Saturday.
Gut microbiome resilience of green-lipped mussels, Perna canaliculus, to starvation
Siming Li [1] ; Tim Young [1] ; Stephen Archer [1] ; Kevin Lee [1] ; Andrea C. Alfaro [1] [1] Auckland University of Technology Localización: International microbiology: official journal of the Spanish Society for Microbiology, ISSN 1139-6709, Vol. 27, Nº. 2, 2024, págs. 571-581 Idioma: inglés Enlaces Texto completo Resumen Host gut microbiomes play an important role in animal health and resilience to conditions, such as malnutrition and starvation.
The world’s top show jumpers return to Doha for the launch of the 2024 Longines Global Champions Tour
Press release The 2024 Longines Global Champions Tour, which brings together the world’s best show jumpers, kicked off in the spectacular Longines Arena at Al Shaqab, Doha from 29 February to 4 March. As the Title Partner and Official timekeeper of the series, Longines timed the brilliant win of Abdel Said (Belgium) on Bonne Amie in the weekend’s highlight trial - the Longines Global Champions Tour Grand Prix of Doha. Media Download images
2023 Longines World Racing Awards Celebrate Equinox, Japan Cup
Press release On 23 January, Swiss watch brand Longines and the International Federation of Horseracing Authorities (IFHA) proudly hosted the 2023 Longines World Racing Awards ceremony in London. Equinox won the 2023 Longines World’s Best Racehorse title, while the Japan Cup in association with Longines (G1) was named the 2023 Longines World’s Best Horse Race. Media Download images
Application of the Improved K-Nearest Neighbor-Based Multi-Model Ensemble Method for Runoff Prediction
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Extended long-term follow-up of metastatic melanoma patients treated with immunotherapy: late relapses and second primary melanomas
Background Immunotherapy has revolutionized the treatment of patients with advanced melanoma as well as other cancers. It is now common for patients with advanced melanoma to have durable complete remissions lasting many years, and disease progression after 5 years seems uncommon. Most studies, however, have only limited follow-up after 5 years, so the incidence of late relapses is uncertain.
Comparison of biospecimens for α‐synuclein seed amplification assays in Parkinson's disease: A Systematic Review and Network Meta‐Analysis
Supporting Information Filename Description ene16041-sup-0001-Supinfo.docxWord 2007 document , 6.7 MB Supplementary Material
Influences of the Runoff Partition Method on the Flexible Hybrid Runoff Generation Model for Flood Prediction
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