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Articles

Light at the ENDothelium-role of Sox17 and Runx1 in endothelial dysfunction and pulmonary arterial hypertension

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By Simmons Beck, Andrea Caporali, Zhiyu Dai, Sophie G. Kellaway
| Frontiers
Introduction The pulmonary circulation is a low-pressure circuit with a mean pulmonary arterial pressure (mPAP) of approximately 14 mmHg. Elevation of mPAP > 20 mmHg is defined as pulmonary hypertension and is common in patients with chronic heart and lung diseases (1, 2), occurring up to 50%–70% of patients.
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