Simon Lovestone

Abstract Objective To determine whether transcriptional risk scores (TRSs), a summation of polarized expression levels of functional genes, reflect the risk of Alzheimer disease (AD). Methods Blood transcriptome data were from Caucasian participants, which included AD, mild cognitive impairment, and cognitively normal controls (CN) in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 661) and AddNeuroMed (n = 674) cohorts.

Correction to: Scientific Reports https://doi.org/10.1038/s41598-018-37431-8, published online 28 February 2019 The original version of this Article contained an error in the title of the paper, where “Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer’s Disease” was incorrectly given as “Pattern of Altered Plasma Elemental Phosphorus, Calcium, Selenium, Iron and Copper in Alzheimer’s Disease”.

1. Background The current landscape of available treatment options for dementia, including Alzheimer's disease (AD), is limited, and researchers have outlined the need for new initiatives to arrive at much-needed breakthrough medications [1x[1]Taylor, J., Marjanovic, S., Nolte, E., Pollitt, A., and Rubin, J. Treatment for dementia: learning from breakthroughs for other conditions. Rand Health Q. 2016; 6: 5 Google ScholarSee all References][1].