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Articles by Simon Steiger
Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment
ArticleOnline nowOpen access Affiliations & Notes 1German Cancer Research Center (DKFZ), JRG Hematology and Immune Engineering, Heidelberg, Germany 2German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany 3Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany 4Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany 5German Cancer Research Center (DKFZ), Division of...
Rainfall increases conformity and strength of species–area relationships
Introduction Species–area relationships constitute a fundamental and almost universally observable pattern in ecology and are thus often considered among the few general ‘laws' governing ecological communities (Schoener 1976, Tjørve and Tjørve 2017). The most common representation of the relationship between species richness and area is Arrhenius' power law, which relates species richness (S) to area (A) through a log-log-linear equation of the form log(S) = c + z × log(A).
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy - Nature Communications
Abstract The long-term consequences of cancer and its therapy on the patients’ immune system years after cancer-free survival remain poorly understood. Here, we present an in-depth characterization of the bone marrow immune ecosystem of multiple myeloma long-term survivors, from initial diagnosis up to 17 years following a single therapy line and cancer-free survival.
Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level - Nature Communications
Abstract In multiple myeloma spatial differences in the subclonal architecture, molecular signatures and composition of the microenvironment remain poorly characterized. To address this shortcoming, we perform multi-region sequencing on paired random bone marrow and focal lesion samples from 17 newly diagnosed patients. Using single-cell RNA- and ATAC-seq we find a median of 6 tumor subclones per patient and unique subclones in focal lesions.
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro - Nature Cell Biology
Abstract The glandular stomach is composed of two regenerative compartments termed corpus and antrum, and our understanding of the transcriptional networks that maintain these tissues is incomplete. Here we show that cell types with equivalent functional roles in the corpus and antrum share similar transcriptional states including the poorly characterized stem cells of the isthmus region.
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