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Highlights • EHMT function during mouse cell reprogramming is modulated by ascorbic acid (AA) • EHMT inhibition counteracts reprogramming in the presence of AA • EHMT inhibition in the presence of AA results in global erasure of H3K9 dimethylation • Cells reprogrammed in the presence of EHMT inhibitor are functionally impaired Summary Methylation of histone 3 at lysine 9 (H3K9) constitutes a roadblock for cellular reprogramming.
We decided to visit Tangier because we’d never crossed the Mediterranean sea — a border easily passed one way, but seldom from the other. The city stands perched at the extreme northern point of North Africa, on a cliff where the continent ends. The waves that come crashing at its feet have come all the way from the Americas, but also from the Strait of Gibraltar, and the Middle East. If you stretch out your fingertips, you can almost touch Spain.
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