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Articles by Simon Weaver
The rise of reducing reagent-resistant TfR1 dimer marks ferroptosis
Abstract Ferroptosis is an iron-dependent type of cell death caused by excessive membrane lipid peroxidation. It remains a challenge to detect ferroptotic cells, especially in in vivo settings, hindering translational studies. Here we discover that a reducing reagent-resistant (3R) dimer of the transferrin receptor 1 (TfR1) is a highly specific indicator for lipid peroxidation.
At COP30 business should focus on positive tipping points
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Business should focus on positive tipping points at COP30
What to expect from COP30 As COP30 gets under way, we explore what is at stake as world leaders, negotiators and activists gather at the climate conference to assess progress since the Paris Agreement
Preview:Harrogate Town vs Newcastle United Under-21s - prediction, team news, lineups
[monks data] EFL Trophy | Gameweek 3 Sports Mole previews Tuesday's EFL Trophy clash between Harrogate Town and Newcastle United Under-21s, including predictions, team news and possible lineups. With progression to the next round already secure, Harrogate Town have the opportunity to claim top spot in their EFL Trophy group when they welcome Newcastle United Under-21s to Exercise Stadium on Tuesday.
Preview: Harrogate Town vs Crewe Alexandra - prediction, team news, lineups
[monks data] League Two Sports Mole previews Monday's League Two clash between Harrogate Town and Crewe Alexandra, including predictions, team news and possible lineups. Harrogate Town will be looking to extend their two-game League Two winning streak when they take on Crewe Alexandra on Monday night. As for Crewe, inconsistent form in September has left them outside the playoff positions, but a victory against the Sulphurites could see them climb back into contention.
Preview: Harrogate Town vs Crawley Town - prediction, team news, lineups
[monks data] League Two | Gameweek 7 Sports Mole previews Saturday's League Two clash between Harrogate Town and Crawley Town, including predictions, team news and possible lineups. Eyeing an outside push for the League Two playoff places, Harrogate Town will welcome struggling Crawley Town to the Exercise Stadium on Saturday afternoon. The Sulphurites are looking for their first win in three games, while the Red Devils are desperate for their first victory of the campaign.
Preview: Harrogate Town vs Lincoln City - prediction, team news, lineups
[monks data] EFL Cup | Gameweek 1 Sports Mole previews Tuesday's EFL Cup clash between Harrogate Town and Lincoln City, including predictions, team news and possible lineups. Harrogate Town will be looking to upset the odds when they welcome Lincoln to the Exercise Stadium for a first round EFL Cup clash this Tuesday night. The Sulphurites have enjoyed a strong start to their League Two season and will be looking to use that momentum when they take on the Imps.
Preview: Harrogate Town vs Grimsby Town - prediction, team news, lineups
[monks data] League Two | Gameweek 2 Sports Mole previews Saturday's League Two clash between Harrogate Town and Grimsby Town, including predictions, team news and possible lineups. Harrogate Town will welcome Grimsby Town to the Exercise Stadium on Saturday for matchday two in the new season. Both sides kicked off their 2024–25 campaigns with wins, with Harrogate claiming a 1–0 victory at Bristol Rovers and Grimsby beating Crawley Town 3–0.
Time for a corporate sustainability reset
New challenges mean business climate leadership must go mainstream Twenty years of working with senior corporate leaders has brought much progress. Now we must work differently to scale up change
Preview: Harrogate Town vs. Fleetwood Town - prediction, team news, lineups
[monks data] League Two | Gameweek 44 CNG Stadium Sports Mole previews Monday's League Two clash between Harrogate Town and Fleetwood Town, including predictions, team news and possible lineups. Harrogate Town will be looking to guarantee their safety in League Two when they go head to head with Fleetwood Town at the Exercise Stadium on Monday.
One-Pot Quantitation of Mycobacterial N-terminal Protein Acetylation Peptidoforms and Proteome
Abstract Isotopic labeling of proteins for quantitative proteomics is a popular technique to increase sample throughput and provide improved accuracy and precision for relative or absolute quantitation between samples. Derivatives of this technique are used to label protein and peptide N-termini for selective enrichment and analysis. We previously reported on a method to enrich and quantify protein N-terminal acetylation in model-system and pathogenic mycobacteria.
Guest Post: Connecting Opportunities With Financial Drivers - Why Businesses Must Embed Sustainability Within Corporate Decision-Making Now More Than Ever
By: Simon Weaver, Global Head of ESG Advisory at KPMG International Previously published on ESG Today NORTHAMPTON, MA / ACCESSWIRE / September 11, 2024 / ESG leaders and CSOs are facing challenges today like never before. Externally, the increasing political polarization of sustainability is forcing leaders to find a delicate balancing act between demonstrating a commitment to ESG and explaining why that commitment genuinely matters and the financial rewards it will bring.
KPMG recognized as a leader in Asia/Pacific Sustainability/ESG Program Management Services
1000 Home › Insights › KPMG recognized as a leader in Asia/Pacific Sustainability/ESG Program Management Services KPMG has been recognized as a leader, in the IDC MarketScape: Asia/Pacific Sustainability/ESG Program Management Services 2024 Vendor Assessment. The report states, “KPMG possesses one of the strongest adjacent digital tools in the market. Its wide range of software offering to supplement its services engagements has empowered KPMG clients even after the services' engagement has ended.
N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum
Abstract Phagosomal lysis is a key aspect of mycobacterial infection of host macrophages. Acetylation is a protein modification mediated enzymatically by N-acetyltransferases (NATs) that impacts bacterial pathogenesis and physiology. To identify NATs required for lytic activity, we leveraged Mycobacterium marinum, a nontubercular pathogen and an estab-lished model for M. tuberculosis. M. marinum hemolysis is a proxy for phagolytic activity. We generated M.
N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum
Abstract Mycobacterial pathogens, including M. tuberculosis, the cause of human tuberculosis, and the non-tubercular species, M. marinum exhibit lytic activity in the host phagosome that is essential for disease. Acetylation is a conserved protein modification that is mediated enzymatically by N-acetyltransferases (NATs). NATs acetylate protein Nɑ-termini, lysine residues, and small mole-cules like antibiotics to alter bacterial physiology and pathogenesis.
Building the business case for sustainability
1000 Home › Insights › Building the business case for sustainability In an era where the impacts of climate change, biodiversity loss, and social inequalities are increasingly evident, affecting the financial viability of companies across the economy. This guide seeks to demystify the process of integrating sustainability into business operations, turning challenges into strategic opportunities.
Analyst recognitions across ESG
1000 Home › Insights › Analyst recognitions across ESG KPMG firms have achieved several recognitions across ESG by independent industry analysts, commending both an internal commitment to sustainability and the services KPMG professionals deliver to clients. We are proud of the commitment KPMG has demonstrated in building a leading ESG team focused on helping clients harness the power of ESG to transform their business.
South Northants Labour Party Candidate, Rufia Ashraf, Campaigns to End Food Poverty
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Labour announce their Parliamentary Candidate for South Northamptonshire
Microsoft Cares About Your Privacy Microsoft and our third-party vendors use cookies to store and access information such as unique IDs to deliver, maintain and improve our services and ads. If you agree, MSN and Microsoft Bing will personalise the content and ads that you see. You can select ‘I Accept’ to consent to these uses or click on ‘Manage preferences’ to review your options and exercise your right to object to Legitimate Interest where used.
KPMG firms recognized as a global leader in ESG and Sustainability Consulting
We are excited to share that KPMG has been named a global leader in the Verdantix Green Quadrant: ESG and Sustainability Consulting 2024. In its report, Verdantix notes: “KPMG leverages its institutional expertise to provide holistic sustainability solutions.
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
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WTW combines Australasia, Asia operations
Willis Towers Watson will combine its Australasia and Asia businesses, appointing a head of Asia Pacific to lead it. Announcing the move, the consultant said the creation of a single APAC business will help unlock potential synergies across markets and increase operational efficiencies. Current head of Australasia Simon Weaver has been appointed to lead the newly formed business as head of Asia Pacific. He will also retain the role of head of corporate risk and broking.
Preparative capillary electrophoresis (CE) fractionation of protein digests improves protein and peptide identification in bottom-up proteomics† Reversed-phase liquid chromatography (RPLC) is widely used to reduce sample complexity prior to mass spectrometry (MS) analysis in bottom-up proteomics. Improving peptide separation in complex samples enables lower-abundance proteins to be identified.
Characterization of DNA aptamer-protein binding using fluorescence anisotropy assays in low-volume, high-efficiency plates
Characterization of DNA aptamer–protein binding using fluorescence anisotropy assays in low-volume, high-efficiency plates† Aptamers have many useful attributes including specific binding to molecular targets. After aptamers are identified, their target binding must be characterized. Fluorescence anisotropy (FA) is one technique that can be used to characterize affinity and to optimize aptamer–target interactions.
A smart approach to smart cities
When looking at Europe’s smart city readiness, the UK is behind on its smart city targets and is at risk of falling behind other European countries, according to research from Citi Horizons. Over 80 per cent of the 187 UK councils asked to take part in this research had limited awareness and little to no involvement in smart cities. The report also warned “it is clear that councils are unable to make smart, connected cities a priority”. But how does a community become smart?
Communications of the ACM
Too Big NOT to Fail Web-scale computing means running hundreds of thousands of servers. It requires a fundamentally different approach from smaller environments. Consistent server hardware and datacenter plans, as well as consistent and simple configurations, are essential. Everything is designed to expect and embrace failure without human intervention. Operations must be largely autonomous. Software must assume crashes. Development, test, and deployment must have integrated and automated solutions.
Do you laugh at offensive jokes? Here's why they're not funny
Some people believe that offensive humour such as sexist or racist jokes can help break down barriers and challenge prejudice. Others simply find it appalling. The topic is clearly sensitive and often leads to discussions about free speech, morality and political correctness. But what can academic research tell us about the implications of offensive joking? We examined the subject looking at jokes about rape that have appeared in the media in recent years with some regularity.
What is the point of offensive humour?
Some people believe that offensive humour such as sexist or racist jokes can help break down barriers and challenge prejudice. Others simply find it appalling. The topic is clearly sensitive and often leads to discussions about free speech, morality and political correctness. But what can academic research tell us about the implications of offensive joking? We examined the the subject looking at jokes about rape that have appeared in the media in recent years with some regularity.
Too Big NOT to Fail
Web-scale computing means running hundreds of thousands of servers. It requires a fundamentally different approach from smaller environments. Consistent server hardware and data center plans, as well as consistent and simple configurations, are essential. Everything is designed to expect and embrace failure without human intervention. Operations must be largely autonomous. Software must assume crashes. Development, test, and deployment must have integrated and automated solutions.
Marcia Gay Harden - TVDRAMA
The feature documentary Code Black, which offers an eyewitness account of doctors making split-second life-and-death decisions in America’s busiest emergency room in L.A. County Hospital, served as inspiration for the eponymous drama series that airs on CBS. The show features the stories, struggles and ambitions of doctors who, when resources in the E.R. are stretched to the limit by the high volume of patients, have to work under the “code black” alert.
Liquid racism and the ambiguity of Ali G
This article analyses Ali G through the concept of ‘liquid racism’. As a polysemic and elusive form, liquid racism requires reflexivity in order to critique it fully, and is a racism that, in media representation, often polarizes debate of its meaning. The article explains how academics have struggled to explain Ali G’s relationship to racism, how his ambiguity is complicated by some social actors seeing him as a real person, before it explains how Ali G expresses three strands of liquid racism.
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