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Simona Lombardi

As seen in: Science Magazine, Texas Medical Center
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Articles

Target antigen-displaying extracellular vesicles boost CAR T cell efficacy in cell and mouse models of neuroblastoma

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By Yaqi Zhang, Dingkang Liu, Anna Maria Giudice, Stephanie Matlaga, Sydney Roth, Guillem Pascual-Pasto, Patrick M. Schürch, Geoffrey T Rouin, Brendan McIntyre, Grant P. Grothusen, Rawan Shraim, David Groff, Simona Lombardi, Daniel Martinez, Anna Maria Giudice, Stephanie Matlaga, Evan Cresswell-Clay, Vincent Zecchino
| Science Magazine Verified
Editor’s summary The effectiveness of CAR T cell therapy for solid tumors has been limited by poor persistence due to immunosuppressive tumor microenvironments, among other factors. Here, Giudice et al. show that neuroblastoma cells released extracellular vesicles (EVs) carrying the tumor antigens glypican-2 (GPC2) and the disialoganglioside GD2. These EVs activated CAR T cells targeting these antigens.
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"Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian" by Simona Lombardi, Aaron R Goldman et al.

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By Aaron Goldman, Hsin-Yao Tang, Andrew V. Kossenkov, Simona Lombardi
| Texas Medical Center
The arginine methyltransferase CARM1 exhibits high expression levels in several human cancers, with the trend also observed in ovarian cancer. However, therapeutic approaches targeting tumors that overexpress CARM1 have not been explored. Cancer cells exploit metabolic reprogramming such as fatty acids for their survival. Here we report that CARM1 promotes monounsaturated fatty acid synthesis and fatty acid reprogramming represents a metabolic vulnerability for CARM1-expressing ovarian cancer.
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