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Articles by Simone Canesi
CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism
Abstract Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report that pharmacological CDK12/CDK13 inhibition (CDK12i) synergistically enhances PT-induced cytotoxicity in a large number of PT-sensitive and PT-resistant EOC models.
Immunohistochemical characterization of cells of the mononuclear phagocyte system in the mouse
Get full access to this article View all access and purchase options for this article. References 1. Aiello S, Noris M, Piccinini G, et al. Thymic dendritic cells express inducible nitric oxide synthase and generate nitric oxide in response to self- and alloantigens. J Immunol. 2000;164(9):4649–4658. 2. Alliot F, Godin I, Pessac B. Microglia derives from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res Dev Brain Res. 1999;117(2):145–152. 3.
Onvansertib treatment overcomes olaparib resistance in high-grade ovarian carcinomas - Cell Death & Disease
Abstract Occurrence of resistance to olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) approved in ovarian carcinoma, has already been shown in clinical settings. Identifying combination treatments to sensitize tumor cells and/or overcome resistance to olaparib is critical. Polo-like kinase 1 (PLK1), a master regulator of mitosis, is also involved in the DNA damage response promoting homologous recombination (HR)-mediated DNA repair and in the recovery from the G2/M checkpoint.
Pneumocystis murina lesions in lungs of experimentally infected Cd40l–/– mice - Andrea Cappelleri, Simone Canesi, Luca Bertola, Valentina Capo, Alessandra Zecchillo, Luisa Albano, Anna Villa, Eugenio Scanziani, Camilla Recordati, 2024
Get full access to this article View all access and purchase options for this article. References 1. Alanen A, Pira U, Colman A, et al. Mott cells: a model to study immunoglobulin secretion. Eur J Immunol. 1987;17:1573–1577. 2. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. Hoboken, NJ: John Wiley & Sons; 2022. 3. Beck JM, Liggitt HD, Brunette EN, et al. Reduction in intensity of Pneumocystis carinii pneumonia in mice by aerosol administration of gamma interferon.
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