Michele Bartoletti
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Managing Enterococcus faecium bloodstream infection: a Delphi document on clinical recommendations and research agenda
Keywords E faecium Bloodstream infection Delphi Management Evidence before this study We conducted a systematic review and meta-analysis of English-language studies published between January 2014 and January 2024 across PubMed-MEDLINE, EMBASE, and Scopus. The existing evidence revealed a fragmented landscape, predominantly composed of observational studies with a moderate risk of bias and a notable absence of randomised controlled trials.
Recommendations on PCV20 vaccine in adults and at-risk populations
Plain-language summary Streptococcus pneumoniae is one of the main causes of pneumonia and meningitis in children and adults. Invasive pneumonia and pneumonia acquired in everyday life are serious manifestations of pneumococcal infection. Adults and children with different immunocompromising conditions and the older population (over 65 years) have a 10 times higher risk of developing serious manifestations of pneumococcal disease, compared to a healthy population.
Longitudinal Prediction of Drug Response in High-Grade Serous Ovarian Cancer Organoid Cultures Aligning with Clinical Responses
Abstract High-grade serous ovarian cancer (HGSOC) ranks among the most aggressive gynecological malignancies. Its high mortality stems from frequent recurrence post-primary treatments and development of platinum resistance. Since, traditional drug development via animal models is time-consuming and lacks reproducibility, in precision cancer medicine, primary patient- derived organoids (PDOs) offer a solution by replicating disease pathophysiology and expediting drug screening.
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