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Michele Bartoletti on Muck Rack

Michele Bartoletti

As seen in: Emerging Infectious Diseases Journal, Nature, Wiley Online Library, Gut Journal, MDPI, BioRxiv, EClinicalMedicine, ersnet.org, Future Medicine, Clinical Microbiology and Infection and
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Articles

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

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By Ilenia Pellarin, Valentina Rossi, Riccardo Giuseppe Margiotta, Javad Karimbayli, Maura Sonego, Laura Molero Sala, Simone Canesi, Andrea Favero, Anna Nespolo, Danilo Licastro, Michele Bartoletti, Fabio Puglisi, Antonino Ditto, Vincenzo Canzonieri, Iain A. McNeish, Guido Sanguinetti, Barbara Belletti, Gustavo Baldassarre, Alessio Polacchini, Ashwani Bahl, Milena Nicoloso, Sara D’Andrea, Monica Schiappacassi
| Nature Verified
Abstract Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report that pharmacological CDK12/CDK13 inhibition (CDK12i) synergistically enhances PT-induced cytotoxicity in a large number of PT-sensitive and PT-resistant EOC models.
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Managing Enterococcus faecium bloodstream infection: a Delphi document on clinical recommendations and research agenda

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By Matteo Rinaldi, Alma Mater Studiorum, Michele Bartoletti
| EClinicalMedicine Verified
Keywords E faecium Bloodstream infection Delphi Management Evidence before this study We conducted a systematic review and meta-analysis of English-language studies published between January 2014 and January 2024 across PubMed-MEDLINE, EMBASE, and Scopus. The existing evidence revealed a fragmented landscape, predominantly composed of observational studies with a moderate risk of bias and a notable absence of randomised controlled trials.
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Recommendations on PCV20 vaccine in adults and at-risk populations

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By Giovanni Sotgiu, Mariangela V. Puci, Michele Bartoletti, Francesco Blasi
| ersnet.org
Plain-language summary Streptococcus pneumoniae is one of the main causes of pneumonia and meningitis in children and adults. Invasive pneumonia and pneumonia acquired in everyday life are serious manifestations of pneumococcal infection. Adults and children with different immunocompromising conditions and the older population (over 65 years) have a 10 times higher risk of developing serious manifestations of pneumococcal disease, compared to a healthy population.
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