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COMMENT 26 October 2026 Academic centres are increasingly central to advanced therapy development, but expanding clinical use will require stronger infrastructure, integrated networks and sustained regulatory and financial support.
Adoptive T cell therapy (ACT) produces durable responses in some cancer patients; however, most tumors are refractory to ACT and the molecular mechanisms underlying resistance are unclear. Using two independent approaches, we identified tumor glycolysis as a pathway associated with immune resistance in melanoma. Glycolysis-related genes were upregulated in melanoma and lung cancer patient samples poorly infiltrated by T cells.
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