Sina Mansour L

Abstract We use connectome modeling to map polysynaptic fiber pathways underlying transcranial magnetic stimulation (TMS) therapy for depression. We propose putative cortical and subcortical routes that connect stimulation sites in the dorsolateral prefrontal cortex to the subgenual cingulate cortex via intermediate regions.

1 Introduction Epilepsy is estimated to affect around 0.6% of the global population [1]. Of these estimated 50 million cases of epilepsy, around 30% are antiepileptic drug-resistant [1]. In 50% of the latter cases, the patient is diagnosed with focal epilepsy [2], where, for a carefully selected subset of patients, the treatment is to resect the culpable region of the brain, known as the epileptogenic zone.

Abstract An individual's connectome is unique. Interindividual variation in connectome architecture associates with disease status, cognition, lifestyle factors, and other personal attributes. While models to predict personal attributes from a person's connectome are abundant, the inverse task-inferring connectome architecture from an individual's personal profile-has not been widely studied.