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Sinethemba Bhebhe

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Articles

Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials

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By Carolyn Williamson, Chivonne Moodley, Craig A Magaret, Elena Giorgi, Morgane Rolland, Dylan Westfall, Anna Yssel, Wenjie Deng, Nonhlanhla N. Mkhize, Lennie Chen, Hong Zhao, Tanmoy Bhattacharya, Alec Pankow, Ben Murrell, Ruwayhida Thebus, Paula Cohen Verified, Bronwen E. Lambson, Michal Juraska, Hongjun Bai, Allan C. deCamp, Maurine D Miner, James Ludwig, Yunda Huang, Lily Zhang, Daniel Reeves, Bryan Mayer, Shelly Karuna, John Hural, Lynn Morris, David C. Montefiori, Penny Moore, Paul T. Edlefsen, Srilatha Edupuganti, Nyaradzo Mgodi, M. Juliana McElrath, Myron Cohen, Lawrence Corey, Peter Gilbert, James Mullins, Raabya Rossenkhan, Talita York, Asanda Gwashu-Nyangiwe, Nonkululeko Ndabambi, Haajira Kaldine, Sinethemba Bhebhe, Cindy Molitor, Nicolas Beaume, David Matten, Roger E. Bumgarner
| Nature Verified
Abstract In the antibody mediated prevention (AMP) trials, the broadly neutralizing antibody (bNAb) VRC01 demonstrated protective efficacy against susceptible HIV strains. To understand how VRC01 shaped breakthrough infections, deep sequencing was performed on 172 participants (>100,000 gag-Δpol and rev-env-Δnef sequences), at diagnosis and over time, in the placebo and treatment arms of the African (HVTN703/HPTN081; NCT02568215) and Americas/Europe (HVTN704/HPTN085; NCT02716675) cohorts.
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