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Sirinapa Srikam

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Articles

Sotagliflozin improves cardiac remodeling and is associated with reduced ER stress–related apoptosis and fibrosis in a rat model of mitral regurgitation

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By Van Dong, Yaowalak Panyasing, Sayamon Srisuwatanasagul, Promporn Raksaseri, Wilawan Ji-au, Sarawut Kumphune, Anusak Kijtawornrat, Sushawadee Tongta, Pakit Boonpala, Nakkawee Saengklub, Sirinapa Srikam, Saikaew Sutayatram, Robert L. Hamlin
| Nature Verified
Abstract Sotagliflozin (SOTA), a dual sodium–glucose cotransporter 1 and 2 (SGLT1/2) inhibitor, reduces adverse cardiovascular outcomes in patients with heart failure; however, its cardioprotective mechanisms in volume overload–induced heart failure remain incompletely understood. We hypothesized that SOTA attenuates maladaptive cardiac remodeling and dysfunction in mitral regurgitation (MR) by suppressing endoplasmic reticulum stress (ERS)–associated apoptosis and fibrotic remodeling.
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