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Sitaramaraju Adduri on Muck Rack

Sitaramaraju Adduri

As seen in: BioRxiv
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Articles

Spatial transcriptomic analysis of HIV and tuberculosis coinfection in a humanized mouse model reveals specific transcription patterns, immune responses and early morphological alteration signaling

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By Sitaramaraju Adduri, Jose Bohorquez, Diego Rincón, Omoyeni Adejare
| BioRxiv
Abstract Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) coinfection is one of the biggest public health concerns worldwide. Both pathogens are adept at modulating immune response and, in the case of Mtb, even inducing structural modification of the affected tissue. The present study aimed at understanding the early phenotypical and functional changes in immune cell infiltration in the affected organ, using a humanized mouse model.
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A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies

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By Guohua Yi, Jose Bohorquez, Danish Ahmed Ansari, Sitaramaraju Adduri
| BioRxiv
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a major public health problem worldwide. The human immunodeficiency virus (HIV) is another equally important life-threatening pathogen. Further, co-infections with HIV and Mtb have severe effects in the host, with people infected with HIV being fifteen to twenty-one times more likely to develop active TB.
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