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Siti Azma Jusoh on Muck Rack

Siti Azma Jusoh

As seen in: BioRxiv
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Articles

Structural Dynamics of LDL Receptor Interactions with E498A and R499G Variants of PCSK9

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By Hapizah Nawawi, Universiti Teknologi MARA, Siti Azma Jusoh, Yung An Chua
| BioRxiv
Abstract The low-density lipoprotein receptor (LDLR) plays an integral role in cellular cholesterol uptake and lipid metabolism by primarily regulating hepatic clearance of plasma low-density lipoprotein cholesterol (LDL-C). Physiologically, proprotein convertase subtilisin/kexin type-9 (PCSK9) attenuates LDLR function by binding to the LDLR extracellular domain, leading to its lysosomal degradation and thereby preventing the total depletion of circulating LDL-C.
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