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Siying Fei on Muck Rack

Siying Fei

As seen in: Frontiers in Immunology
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Articles

Injured proximal tubule-driven paracrine signaling promotes lipid-associated macrophage expansion and chondroitin sulfate biosynthesis via PPARG/TCF12 in diabetic kidney disease

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By Zihan Dou, Ming Cai, Xiaobin Mei, Bingshu Wu, Siying Fei, Suxuan Liu
| Frontiers in Immunology
Abstract Background: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, yet its immune-mediated pathogenesis remains incompletely understood. Lipid-associated macrophages (LAMs) have emerged as key mediators of metabolic tissue injury, but their role in DKD and the upstream signals governing their transcriptional programs are undefined.
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