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Siying Xu on Muck Rack

Siying Xu

As seen in: Nature
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The deubiquitinase USP4 stabilizes the SCFFBXO24 ubiquitin E3 ligase to regulate immunity in experimental pneumonia

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By Ilknur Yurtsever, Daniela Farkas, Alex Cornwell, Jessica Joseph, Joseph S. Bednash, James Londino, Benjamin Johnson, Rama K. Mallampalli, Siying Xu, Joshua A. Englert
| Nature Verified
Abstract The ubiquitin E3 ligase SCFFBXO24 targets key proteins for degradation that regulate important biological processes, but the mechanisms controlling cellular concentrations of its receptor subunit, F-box only protein 24 (FBXO24), remain unknown. Here, Haemophilus influenzae type B (HiB), an important cause of pneumonia, protects FBXO24 from lysosomal degradation in THP-1 macrophage cells by reducing its ubiquitylation levels.
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