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ASXL2 Mutations Are Associated with Overall Survival and Estrogen Receptor Status in TCGA-BRCA Breast Cancer Patients

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By Anton V. Sinitskiy, Siyona Bhagwat
| preprints.org
You are already at the latest version Identifying mutations associated with both estrogen receptor (ER) status and patient survival may improve biomarker-based stratification in breast cancer. Here, we analyzed the TCGA-BRCA dataset to identify genes whose mutation status is linked to both ER phenotype and overall survival. In a screen of the top 20 candidate genes, most genes showed evidence for only one clinical association, whereas ASXL2 was significantly associated with both endpoints.
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