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Siyu Gai

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Articles

Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT2A - Nature Communications

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By Siyu Gai, Li Lin, Yichen Wu, Li Xue, Chanjuan Xu, Qian Sun, James Dalton, Jesús Giraldo, Jean-Philippe Pin, Philippe Rondard, Jianfeng Liu, Jiyong Meng, Adrià Ricarte, Pedro Renault
| Nature Verified
Abstract G protein-coupled receptor (GPCR) dimers and higher-order oligomers are the subject of intense debates. The complexes formed between two or more different GPCRs enable the cell to integrate several signals. But the mechanisms of the allosteric interaction within these oligomers remain unclear. Here, we use as a model the heteromer formed in the brain between two targets of anti-psychotic drugs, the metabotropic glutamate receptor 2 (mGlu2) and the serotonin receptor 5-HT2A.
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[2210.11934] An Analysis of Fusion Functions for Hybrid Retrieval

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By Siyu Gai, Amir Ingber
| arxiv.org
[Submitted on 21 Oct 2022 ( v1 ), last revised 4 May 2023 (this version, v2)] Title:An Analysis of Fusion Functions for Hybrid Retrieval Download a PDF of the paper titled An Analysis of Fusion Functions for Hybrid Retrieval, by Sebastian Bruch and Siyu Gai and Amir Ingber Download PDF Abstract: We study hybrid search in text retrieval where lexical and semantic search are fused together with the intuition that the two are complementary in how they model relevance.
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The GABAB receptor mediates neuroprotection by coupling to G13

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By Androniqi Qifti, Yunyun Wang, Ganapathy Sriram, Siyu Gai
| Science Magazine Verified
Yunyun Wang https://orcid.org/0000-0001-8421-8370, Siyu Gai https://orcid.org/0000-0002-4843-943X, Wenhua Zhang https://orcid.org/0000-0003-0230-9856, Xuetao Huang, Shumin Ma, Yujia Huo, Yichen Wu, Haijun Tu https://orcid.org/0000-0002-8960-856X, Jean-Philippe Pin https://orcid.org/0000-0002-1423-345X, Philippe Rondard https://orcid.org/0000-0003-1134-2738, Chanjuan Xu https://orcid.org/0000-0002-5640-1896 , and Jianfeng Liu https://orcid.org/0000-0002-0284-8377 Another G for GABAB receptor...
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