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Snider Desir

As seen in: Nature, MDPI
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Articles

Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

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By Snider Desir, Phillip Wong, Thomas J. Turbyville, De Chen
| MDPI
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Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer

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By Rachel Isaksson Vogel, Snider Desir, Patrick O’Hare, William Sperduto
| Nature Verified
There is significant heterogeneity in tumor-stroma proportions between patients, even within the same type of cancer. This biologic characteristic poses a challenge to achieving uniform efficacy of targeted therapeutics in many solid tumor types. This is especially true in pancreatic carcinomas, in which the stromal matrix is particularly dense as a result of desmoplastic reaction that takes places throughout the process of tumor formation35,36.
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