Sobha Karuthedom on Muck Rack

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Injectable shear thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors

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By Emine Alarçin, Tae Yong Lee, Meadhbh Brennan, Sobha Karuthedom
| Royal Society of Chemistry Verified
Bone nonunion may occur when the fracture is unstable, or blood supply is impeded. To provide an effective treatment for healing of nonunion defects, we introduce an injectable osteogenic hydrogel that can deliver cells and vasculogenic growth factors. We used a silicate-based shear-thinning hydrogel (STH) to engineer an injectable scaffold and incorporated polycaprolactone (PCL) nanoparticles that entrap and release vasculogenic growth factors in a controlled manner.
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