Sofia Barluenga

A standard analytical HPLC system is repurposed into a fully automated, flow-based peptide synthesis platform. By leveraging the autosampler for automated reagent injections into a resin-packed guard...

Abstract Antibody–drug conjugates enable highly specific delivery of potent cytotoxics to biomarker-expressing cells. In parallel, advances in DNA circuitry and DNA–protein conjugates have allowed programmable integration of molecular inputs and signal amplification via hybridization chain reactions (HCRs).

Introduction Click to copy section linkSection link copied! Pleckstrin homology (PH) domains are critical structural motifs found in a wide variety of proteins involved in intracellular signaling and cytoskeletal organization. Initially identified in the platelet protein pleckstrin, (1) these prevalent, approximately 120 amino acid domains represent the 11th most abundant distinct 3D protein fold.