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Abstract Oxylipin species are generated from omega-3 and omega-6 fatty acids during inflammation, including fatty acid epoxides by cytochrome P450s (CYP450) and their diol metabolites by soluble epoxide hydrolase (sEH). The CYP450-sEH pathway has been implicated in Alzheimer’s disease (AD) but it remains unclear how plasma oxylipins relate to AD biomarkers and neurodegeneration.
1 Introduction Type 2 diabetes mellitus (T2DM) is increasingly prevalent, posing a substantial personal and public health problem. Most people with T2DM will experience at least one diabetes complication in their lifetime, which may include dementia (Zheng et al. 2018). T2DM increases dementia risk by 60% (Gudala et al. 2013).
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