Sofia Sindici Forgiarini on Muck Rack

Sofia Sindici Forgiarini

As seen in: Wiley Online Library, British Pharmacological Society
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Articles

Inosine-Triphosphate-Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

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By Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci
| Wiley Online Library Verified
INTRODUCTION Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood and is characterized predominantly by immune-mediated inflammatory arthritis with a heterogenous clinical presentation.1, 2 Low-dose methotrexate (MTX), which is highly effective both as monotherapy and in combination with biologic drugs, is a first-line therapy in JIA.3 As a folate analog, MTX modulates pathways that involve folates, including the de novo synthesis of purines and...
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Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism - Franzin - British Journal of Pharmacology - Wiley Online Library

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By Martina Franzin, Cristina Lagatolla, Mathias Haag, Sofia Sindici Forgiarini
| British Pharmacological Society
AZA azathioprine CD Crohn' disease CPS capsular polysaccharide dTGTP deoxythioguanosine triphosphate dTGUA deoxythioguanosine HPLC-UV high performance liquid chromatography coupled with a UV detector IBD Inflammatory bowel disease IQR interquartile range LC–MS/MS liquid chromatography tandem mass spectrometry LC-QTOF-MS liquid chromatography time-of-flight mass spectrometer MIC minimum inhibitory concentration MeTG methylthioguanine MeTGDP methylthioguanosine diphosphate MeTGMP...
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