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Sofia Soltero

As seen in: BioRxiv, Genes and Development Journal
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Articles by Sofia Soltero

Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway

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By Allison E. Daly, George Yeh, Sofia Soltero, Stephen T. Smale
| Genes and Development Journal
1,2,3 1Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA; 2Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA; 3Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California 90095, USA Corresponding author: smale{at}mednet.ucla.edu Footnotes Supplemental material is available for this article.
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Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway

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By Allison E. Daly, Stephen T. Smale, George Yeh, Sofia Soltero
| BioRxiv
Abstract The five NF-κB family members and three nuclear IkB proteins play important biological roles,but the mechanisms by which distinct NF-κB and IκB proteins contribute to selective gene transcription remain poorly understood, especially at a genome-scale level. Using nascent transcript RNA-seq, we observed considerable overlap between p50-dependent and IκBζ-dependent genes in Toll-like receptor 4 (TLR4)-activated macrophages.
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