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Abstract Conventional type I dendritic cells (cDC1s) undergo homeostatic maturation upon apoptotic cell engulfment, hallmarked by the activation of the transcription factor LXRβ, which mediates cholesterol efflux and dampens interferon-stimulated gene expression. Here, we identify the unfolded protein response sensor IRE1 as an essential regulator of this process. Loss of IRE1 impairs cDC1, but not cDC2, homeostatic maturation and survival.
1 INTRODUCTION The term immunogenicity was coined for the very first time in 19691, 2 to describe the capacity of an antigenic molecule to provoke a cell-mediated immune response.
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