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Sofya Novikova

As seen in: BioRxiv
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Articles

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

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By Dan Albers, Yasser Almeida-Hernandez, Sofya Novikova, Julio Vieyto-Nunez
| BioRxiv
Abstract GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement in inflammatory disorders and cancers. This study investigates the effects of GPR15LG on the signaling and downstream functions of C-X-C chemokine receptor type 4 (CXCR4), which plays a critical role in immune cell trafficking and cancer metastasis.
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