Sohyung Lee

Abstract Achieving ultra-long-term release of hydrophilic drugs over several months remains a significant challenge for existing long-acting injectables (LAIs). Existing platforms, such as in situ forming implants (ISFI), exhibit high burst release due to solvent efflux and microsphere-based approaches lead to rapid drug diffusion due to significant water exchange and large pores.

Abstract Although hydrophilic drugs represent a large proportion of all therapeutics used to treat and manage chronic diseases, achieving their ultra-long-term delivery via an injectable system remains a major challenge. Implants have demonstrated potential for long term delivery of both hydrophobic and hydrophilic drugs; however, they require invasive insertion process in a sterile setting, which restricts their suitability for resource limited settings.

Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2021, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Sohyung Lee Sohyung Lee Department of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, California 90095, United States , Joseph de Rutte Joseph de Rutte Partillion Bioscience, Los Angeles, California 90095, United States Department of Bioengineering, University of California - Los Angeles, Los Angeles, California 90095, United...