Soile Tapio

Limitations A concerning feature of our meta-analysis is that for many endpoints, and in particular for cerebrovascular disease, heterogeneity was significant (P<0.001), and this together with high values (generally >50%) of the I2 statistic imply that a material proportion of the variance was due to interstudy heterogeneity (table 3). This issue makes interpretation of summary measures of risk problematic.