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Abstract Objective: To systematically evaluate published nomograms developed for patients with locally advanced cervical cancer (LACC) treated with radiotherapy, focusing on prognostic performance, core predictive variables, and implications for future model development.
Highlights • A nationwide next-generation sequencing registry of 779 patients with ovarian cancer was analysed. • At least one pathogenic mutation of the actionable genes was found in 49.2% of patients. • The comutations of TP53 and KRAS or PIK3CA were observed in 5% and 4% of patients, respectively. • Substantial BRCA1/2 mutations (25.9%) were found in patients without a TP53 mutation. • PTCH1 mutations were correlated with ATM, NF1, ERBB2 and MTOR mutations.
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