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Soledad Reyes Nabora on Muck Rack

Soledad Reyes Nabora

As seen in: BioRxiv
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Articles

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

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By Jinyoung Lee, Sakshi Goel, Soledad Reyes Nabora, Sang-Ho Woo
| BioRxiv
Abstract Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characterization of senescent cells in the native tumor niche. Here, we identified senescent p16Ink4a+ cancer-associated fibroblasts with a secretory phenotype that promotes fatty acid uptake and utilization by aggressive lung adenocarcinoma driven by Kras and p53 mutations.
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