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Somar Khalil

As seen in: BioRxiv
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Articles

Comparative analysis of MS/MS search algorithms in label-free shotgun proteomics for monitoring host-cell proteins using trapped ion mobility and ddaPASEF

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By Michel Plisnier, Somar Khalil
| BioRxiv
Abstract Host cell proteins (HCPs) are critical quality attributes that can impact the safety, efficacy, and quality of biotherapeutics. Label-free shotgun proteomics is a vital approach for HCP monitoring, yet the choice of tandem mass spectrometry (MS/MS) search algorithms directly influences identification depth and quantification reliability.
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Characterization and Validation of a Middle-Down Hydrophobic Interaction Chromatography Method to Monitor Methionine Oxidation in IgG1

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By Nisha Patel, Cyrille Chéry, Somar Khalil, Francoise Bevillard-Kumar
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.02.01.525715 Abstract Post translational modifications (PTMs) of therapeutic monoclonal antibodies (mAbs) can impact the efficacy of a drug. Methionine oxidation can alter the overall hydrophobicity of an antibody, thereby inducing conformational changes and affecting its biological activity. To ensure high quality, safety, and efficacy of mAbs, routine monitoring of PTMs such as methionine (Met) oxidation is essential.
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