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Somashekarappa Gowda Nanjappa on Muck Rack

Somashekarappa Gowda Nanjappa

As seen in: The Journal of Immunology
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Articles

Anti-Fungal Functional Tc17 Cells Persist as Long-Lasting Memory Without Plasticity Towards IFNγ

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By Publ. Hlth, Somashekarappa Gowda Nanjappa, Scott Fites
| The Journal of Immunology Verified
Memory homeostasis of Th1/Tc1 cells is well characterized, whereas memory Th17-cell homeostasis, persistence and plasticity are debated. We have shown that IL-17A-producing CD8+ T-cells (Tc17) are necessary for vaccine-induced fungal immunity in CD4+ T-cell compromised hosts. Here, we systematically evaluated persistence, fidelity, plasticity and functional role in immunity of anti-fungal Tc17 cells using IL-17A fate-mapping reporter mice.
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