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Somesh M. Gorde on Muck Rack

Somesh M. Gorde

As seen in: Nature, BioRxiv
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Articles

An ER-resident lipid scramblase is crucial for biogenesis and function of apicomplexan parasite secretory organelles - Nature Communications

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By G. Srinivas Reddy, Somesh M. Gorde, KANIKA SAXENA, Abhijit S. Deshmukh
| Nature Verified
Abstract Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, contain specialized secretory organelles such as micronemes, rhoptries, and dense granules, which are essential for parasite motility, host cell invasion, development, and egress. DedA superfamily proteins are implicated in lipid mobilization, which is a key requirement for organelle biogenesis. Herein, we identify and investigate the vacuole membrane protein 1 (VMP1), a DedA superfamily member, of P.
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An ER-resident lipid scramblase is crucial for biogenesis and function of apicomplexan parasite secretory organelles

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By G. Srinivas Reddy, Somesh M. Gorde, KANIKA SAXENA, Manash Kumar Behera
| BioRxiv
Abstract Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, contain specialized secretory organelles such as micronemes, rhoptries, and dense granules, which are essential for parasite motility, host cell invasion, development, and egress. DedA superfamily proteins are implicated in lipid mobilization, which is a key requirement for organelle biogenesis. Herein, we identified and investigated the vacuole membrane protein 1 (VMP1), a DedA superfamily member, of P.
Open in Who Shared Issue with article?

The apicomplexan DedA superfamily protein VMP1 is crucial for the biogenesis and function of secretory organelles

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By G. Srinivas Reddy, Somesh M. Gorde, KANIKA SAXENA, Manas Behera
| BioRxiv
Abstract Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, contain specialized secretory organelles like micronemes, rhoptries, and dense granules, whose secretions are essential for various parasite activities. As lipid mobilization is key for organelle biogenesis and function, we investigated if the DedA superfamily lipid scramblase vacuole membrane protein 1 (VMP1) has a role in the biogenesis and function of apicomplexan secretory organelles.
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