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Sơn Lê

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Articles

Direction-resolved nanoscale optical imaging with near-nanometer resolution by emerging infrared torsional force microscopy

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By Son Le, Sơn Lê, Aubrey T. Hanbicki, Adam Friedman Verified, Min Ouyang, Yonatan Gazit
| Nature Verified
Abstract Resolving nanoscale light-matter interactions requires both high spatial resolution and anisotropic sensitivity to in-plane and out-of-plane optical responses. We introduce torsional force microscopy-infrared microscopy, a new optical imaging technique that combines cantilever torsional dynamics with a nonlinear frequency-mixing scheme to map both in-plane and out-of-plane photothermal signals.
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Reusable Agents Meet Generative UIs: Announcing Open Agent Specification support for A2UI through CopilotKit AG-UI

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By Son Le, Sơn Lê, Sungpack Hong, Damien Hilloulin
| Oracle
Agent frameworks have become great at reasoning, orchestration, and tool execution. But the moment you want to ship a real product experience, such as interactive UI, mid-run progress, state that stays in sync, you often end up rebuilding the same “middle layer” in every stack.
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Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial - Nature Communications

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By Jian L. Campian, Son Le, Sơn Lê, Ashley Ghiaseddin, Omar Butt, Dongjiang Chen, Yifei Xu, Jingxia Liu, Maryam Rahman, William A. Leidig, George Ansstas, Alice Zhou, Sangami Pugazenthi, Gavin P. Dunn, Jiayi Huang, Milan G. Chheda, Albert Kim, Eric C. Leuthardt, David Tran, David Trần, Harshit Manektalia, Nathan Thai, Tanner Johanns
| Nature Verified
Abstract Immune checkpoint inhibitors (ICIs) show minimal efficacy in recurrent high-grade astrocytoma (rHGA). Laser interstitial thermal therapy (LITT), a minimally invasive cytoreductive approach, may prime rHGA for ICI response. A phase 1/randomized phase 2b trial (ClinicalTrials.gov: NCT02311582) was designed to test pembrolizumab in combination with LITT in patients with rHGA. Nine patients were enrolled in the phase I dose-escalation lead-in study.
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