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Song-bin Liu on Muck Rack

Song-bin Liu

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Articles

BDKRB2 upregulation by dystrophic microglia drives pain hypersensitivity in aged mice

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By An Liu, Ming-jun Zhang, Jin-rong Guo, Han Chu, Dan-Yang Chen, Peng Cao, Zhi Zhang, Song-bin Liu, Yuan-zhong Kai
| Nature Verified
Abstract Although pain sensitization is among the most common conditions affecting the elderly, its underlying neural mechanisms remain unclear. Here, we found that mechanical hypersensitivity arises from enhanced glutamatergic excitability in primary somatosensory cortex due to bradykinin receptor B2 (BDKRB2) upregulation by dystrophic microglia during aging.
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