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Song-bo Xie

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BioPROTACs: a promising approach for targeted protein degradation

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By Yu-yang Li, Ren-Shuai Zhang, Li-Li Yang, Xin-Yu Wang, Xue-Wei Cao, Fu-ru Zhang, Dong-ling Shao, Shu-ang Sun, Rui-xin Ge, Song-bo Xie
| Nature Verified
Abstract Targeted protein degradation (TPD) has emerged as an important therapeutic strategy in recent years. Proteolysis-targeting chimeras (PROTACs) are among the most extensively studied TPD technologies that eliminate target proteins through a “degradation rather than inhibition” mechanism. This mechanism offers opportunities to target proteins that are difficult to modulate using conventional small-molecule inhibitors and may also help mitigate drug resistance.
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