Song-Ou Zhang

As seen in: Frontiers in Immunology

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Mitochondrial-targeted therapy for osteoarthritis: Challenges and opportunities from basic research to clinical translation

Feb 20, 2026 |

By Jian Ruan, Jian Zhang, Hong Ru Chen, Song-Ou Zhang, Zhi-Qian Gu

| Frontiers in Immunology

Abstract Osteoarthritis is a high-burden degenerative joint disease. Existing therapies only alleviate symptoms but fail to halt disease progression. Studies have identified mitochondrial dysfunction as a core driver of cartilage degeneration in OA.

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Song-Ou Zhang

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Mitochondrial-targeted therapy for osteoarthritis: Challenges and opportunities from basic research to clinical translation

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