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Abstract We tested the concept that host preexisting influenza A virus immunity can be redirected to inhibit tumor growth and metastasis through systemic administration of influenza A virus-related peptides to targeted tumors. Mice infected with influenza A virus strain A/Puerto Rico/8/34 (PR8) were used as a model of a host with preexisting viral immunity.
Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells Cetuximab, an epidermal growth factor receptor (EGFR)-blocking antibody, was approved for treatment of metastatic colorectal cancer over a decade ago; however, patients’ responses to cetuximab vary substantially due to intrinsic and acquired resistance to cetuximab.
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