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Songlin Yin

As seen in: Nature
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Articles

Intermediate accumulated upon interruption of fatty acid oxidation flux promotes tumoral ferroptosis and improves immunotherapy

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By Yuhan Zhou, Jing Li, Fangfang Liu, Yuan Gao Verified, Songlin Yin, Liguo Yang, Xiaoxiao Li, Junhong Lin, Haotian Shang, Xiang Cheng, Tengfei Chao, Qian Chu, Fujia Lu, Weimin Wang
| Nature Verified
Abstract Therapeutic strategies targeting cancer metabolism are advancing rapidly. However, perturbing distinct nodes within the same metabolic pathway often yields divergent outcomes. Ferroptosis, a metabolic cell death driven by lipid peroxidation, has garnered attention for potentiating antitumor immunity. Here, we demonstrate that interruption of fatty acid oxidation (FAO) at hydroxyacyl-CoA dehydrogenase (HADHA) node promotes tumoral ferroptosis, whereas targeting upstream enzymes does not.
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TMEM87A suppresses ferroptosis and increases cancer immunotherapy resistance by maintaining the Golgi apparatus pH homeostasis

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By Jing Li, Yuhan Zhou, Xiong Li, Songlin Yin, Yuan Gao Verified, Haotian Shang, Yongfeng Lai, Liguo Yang, Ying Xue, Xiaoxiao Li, Zhenzhen Chang, JING CHEN, Xiang Cheng, Xiaoyan Zhang, Qian Chu, Fujia Lu, Weimin Wang
| Nature Verified
Abstract Most membrane-bound organelles have been linked to the initiation and execution of ferroptosis. However, the role of the Golgi apparatus and its resident proteins in ferroptosis remain elusive. Here we show that ferroptosis inducer triggers rapid oxidation of Golgi membrane lipids in the early phase of ferroptosis, resulting in disruption of Golgi pH. The Golgi-localized transmembrane protein TMEM87A is identified to mediate ferroptosis resistance through buffering Golgi pH.
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Enhanced Prediction of Sea Surface Temperature Using Empirical Mode Decomposition-Gated Recurrent Unit

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By Jingjing He, Songlin Yin, Xianyao Chen, Bo Yin
| ametsoc.org
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