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Songyin Huang on Muck Rack

Songyin Huang

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Articles

Membranolytic peptide programs immunogenic cell death for cancer therapy

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By Yueling Yuan, Lifang Liang, Jie Li, Fuxiang Wang, Kai Yan, Jingxian Chen, Fan Lan, Zining Wu, Rupei Du, Yaofeng Zhou, Long Zou, Zhouming Zhang, Yuhao Zhang, Yajing zhang, Penghui Zhou, Tianmeng Sun, Kaiting Yang, Zhibin Zhao, Zhexiong Lian, Shiyan Xiao, Jianjun Cheng, Yan Bao, Menghua Xiong, Chengrun Li, Chanjuan Su, Xiongwei Xiang, Jueqiong Xu, Huosheng Zhou, Songyin Huang
| Nature Verified
Abstract A rational design for facilitating innovative cell death modes can substantially aid advances in antitumour therapy1,2. Here we design and implement a unique mode of immunogenic membranolytic cell death (mLCD) in tumour cells, characterized by time-lagged rupture from the lysosomal to plasma membranes; this approach was found to robustly potentiate immune checkpoint blockade therapy.
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