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Articles by Sonia Borrell
LysG-driven transcriptional network rewiring underlies lineage-specific phenotypes in Mycobacterium tuberculosis
Abstract The Mycobacterium tuberculosis complex (MTBC) includes ten human-adapted lineages with varying geography and pathogenicity. Lineage 1 (L1) shows low virulence while Lineage 2 (L2) is hyper-virulent, more transmissible, and associated with drug-resistance. We performed comparative analyses integrating whole-genome sequencing with transcriptomic and proteomic profiling of L1 and L2 clinical strains under two in vitro growth conditions.
Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia - Genome Medicine
Between 1st October 2010 and 31st December 2023, M. tuberculosis isolates from all bacteriologically confirmed MDR-TB cases were collected and cultured at the National Center for Tuberculosis and Lung Disease in Tbilisi (NCTLD), Georgia. Additionally, a separate subset of M. tuberculosis isolates from all TB cases (including drug-susceptible cases) was collected between the years 2014–2016 (Additional File 1: Fig S1). All isolates were derived from routine diagnostic sputum samples.
Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
eLife Assessment This study describes the impact of mycobacterial genetic diversity on host-infection phenotypes by assessing the effect of different M. tuberculosis lineages on granulomatous inflammation using a 3D in vitro granuloma model. Despite being descriptive and showing mostly correlative relationships, the findings are useful and provide some solid support regarding the functional impact of M. tuberculosis's natural diversity on host-pathogen interactions.
Parc eòlic del pic de Maià?
Des de l’ARPA ens trobem profundament preocupats davant la proposta de construir un parc eòlic al pic de Maià. Això representa no només una amenaça greu per al nostre entorn natural, sinó també un canvi dràstic en la identitat paisatgística d’Andorra. Entenem i compartim la necessitat de buscar alternatives energètiques sostenibles.
CXCL9, granzyme B and TNF-alpha orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
Abstract The members of the Mycobacterium tuberculosis complex (MTBC) causing human tuberculosis comprise ten phylogenetic lineages that differ in their geographical distribution. The human consequences of this phylogenetic diversity remain poorly understood. Here, we assessed the phenotypic properties at the host-pathogen interface of 14 clinical strains representing five major MTBC lineages.
HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa
Abstract Persons living with HIV are known to be at increased risk of developing tuberculosis (TB) disease upon infection with Mycobacterium tuberculosis (Mtb). However, it has remained unclear how HIV co-infection affects subsequent Mtb transmission from these patients. Here, we customized a Bayesian phylodynamic framework to estimate the effects of HIV co-infection on the Mtb transmission dynamics from sequence data.
Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis
The health span of supercentenarians might be partly explained by the expansion of T cells that kill infected or abnormal cells.
A New Phylogenetic Framework for the Animal-adapted Mycobacterium tuberculosis Complex
A New Phylogenetic Framework for the Animal-adapted Mycobacterium tuberculosis Complex Daniela Brites, Chloe Loiseau, Fabrizio Menardo, Sonia Borrell, Maria Beatrice Boniotti, Robin Warren, Anzaan Dippenaar, Sven David Charles Parsons, Christian Beisel, Marcel A. Behr, Janet A Fyfe, Mireia Coscolla, Sebastien Gagneux bioRxiv 384263; doi: https://doi.org/10.1101/384263
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