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Sonia El Mouridi on Muck Rack

Sonia El Mouridi

As seen in: Nature, Science Magazine, BioRxiv
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Articles

Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans

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By Jessica Kirshner, Philip Woods, Ben Title, Colette L. Picard, Natasha E. Weiser, Nicita Mehta, Suhua Feng, Victoria Murphy, Sonia El Mouridi, Christian Frøkjær-Jensen, Steven E. Jacobsen, John Kim, Anna Vakhnovetsky, Amelia F. Alessi, Connie Xiao, Kai Inoki
| Science Magazine Verified
Abstract The Argonaute CSR-1 is essential for germline development in C. elegans. Loss of CSR-1 leads to the down-regulation of thousands of germline-expressed genes, supporting a model in which CSR-1 “licenses” gene expression via a poorly understood mechanism. In contrast, a small subset of genes is up-regulated in csr-1 mutants, including morc-1, which encodes a conserved GHKL-type ATPase.
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In vivo reprogramming of Caenorhabditis elegans leads to heterogeneous effects on lifespan

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By Sonia El Mouridi, Sara Picó, Alba Acosta, Yann Mauge
| BioRxiv
Abstract In the last decade, cellular reprogramming of fully differentiated cells to pluripotent stem cells has become of great interest. Importantly, cellular reprogramming by expression of Oct4, Sox2, Klf4, and cMyc (OSKM) can ameliorate age-associated phenotypes in multiple tissues and extend lifespan in progeroid and aged wild-type mice. Surprisingly, the effects of in vivo reprogramming have not been deeply investigated in any other model organisms.
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Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

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By Mohammed AlJohani, Christian Frøkjær-Jensen, Sonia El Mouridi, Amhed M. Vargas-Velazquez
| Nature Verified
Abstract Transgenes are prone to progressive silencing due to their structure, copy number, and genomic location. In C. elegans, repressive mechanisms are particularly strong in the germline with almost fully penetrant transgene silencing in simple extrachromosomal arrays and frequent silencing of single-copy transgene insertions. A class of non-coding DNA, Periodic An/Tn Clusters (PATCs) can prevent transgene-silencing in repressive chromatin or from small interfering RNAs (piRNAs).
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