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Sonia Yip

As seen in: Nature, Cell Reports Medicine, Journal of Clinical Oncology
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Articles by Sonia Yip

Olaparib in HR-deficient, metastatic triple-negative breast and platinum-sensitive relapsed ovarian cancers without germline mutations in BRCA1/2 : phase 2 EMBRACE trial

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By Katrin M. Sjoquist, Alexander Dobrovic, Kristy P. Robledo, Ksenija Nesic, Sally Baron-Hay, Nicole McCarthy, Jeffrey Goh, Christopher Steer, Sonia Yip, Linda Mileshkin, J. Lynn Fink, Lisa Bailey, Yvonne Lee, Danka S Zebic, Kristy Shield-Artin, Anthony T. Papenfuss, Olga Kondrashova, Matthew Wakefield, Cassandra J. Vandenberg, Martin R. Stockler, Clare Scott Verified, Paul M. Waring, Sumitra Ananda, Garry Chang, U. G. Imalki U. Kariyawasam, Andrew Jarratt
| Nature Verified
Abstract Homologous recombination (HR) deficiency (HRD) from germline BRCA1/2 mutations (gBRCAm) sensitizes high-grade serous ovarian cancer (HGSOC) and triple-negative breast cancer (TNBC) to PARP inhibitors (PARPi), as may promoter methylation of BRCA1 (meBRCA1) or RAD51C (meRAD51C) or mutation of non-BRCA HR genes. This trial evaluated olaparib in platinum-sensitive, relapsed HGSOC (PSROC) and metastatic TNBC (mTNBC) with non-gBRCA HRD.
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Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy

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By Wee Loong Chin, Jonathan Chee, Nicola Principe, Tracy Hoang, Joel Kidman, Yen Yeow, Matthew Jones, Rui Hou, Elena Denisenko, Alison McDonnell, Chung-Chau Hon, Jonathan Moody, Denise Anderson, Sonia Yip, Michelle M Cummins, Martin R. Stockler, Peey-Sei Kok, Chris Brown Verified, Thomas John, Deme Karikios, Kenneth J. O’Byrne, Brett Hughes, Richard Lake Verified, Alistair Forrest Verified, Timo Lassmann, W. Joost Lesterhuis, Alistair M. Cook, Khaing P.W. Hmon, Steven C.-H. Kao
| Cell Reports Medicine Verified
Keywords immune checkpoint therapy ICT platinum chemotherapy mesothelioma single-cell RNA sequencing biomarkers response peripheral blood cancer CD8+ T effector memory cells PD-L1 Introduction Pleural mesothelioma is a rare malignancy linked to asbestos exposure.
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Regorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial

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By Andrew Martin Verified, Katrin M. Sjoquist, Eric Tsobanis, Sonia Yip
| ascopubs.org
Presented at the 51st Annual Meeting of the American Society of Clinical Oncology, Chicago, IL, May 29-June 2, 2015, and the 17th European Society for Medical Oncology World Congress on Gastrointestinal Cancer, Barcelona, Spain, July 1-4, 2015. Purpose We evaluated the activity of regorafenib, an oral multikinase inhibitor, in advanced gastric adenocarcinoma.
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