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Sonogenetic Neuromodulation

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Articles

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

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By Xuandi Hou, Jianing Jing, Sonogenetic Neuromodulation
| Wiley Online Library Verified
1 Introduction Ultrasound (US) is a form of mechanical energy that can penetrate the intact skull and reach deep brain regions, enabling spatially and temporally controlled neuromodulation [1-3]. Low-intensity ultrasound has shown promise in modulating the activity of the cortex and deep brain nuclei for treating various brain disorders in humans [4-6]. However, conventional transcranial ultrasound lacks the precision necessary to selectively modulate specific types of neurons [7].
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