Soo Hyeon Bae

What is already known about this subject Sodium–glucose cotransporter 2 inhibitors provide effective hypoglycaemic therapy and are innovative agents for optimizing clinical therapy for type 2 diabetes mellitus patients. A pharmacokinetic/pharmacodynamic model has been established for dapagliflozin, a comparator drug, by adopting generally used approaches to translate nonclinical data to humans.

Abstract : Humans are continuously exposed to benzisothiazolinone (BIT), which is used as a preservative, through multiple routes. BIT is known to be a sensitizer; in particular, dermal contact or aerosol inhalation could affect the local toxicity. In this study, we evaluated the pharmacokinetic properties of BIT in rats following various routes of administration. BIT levels were determined in rat plasma and tissues after oral inhalation and dermal application.