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Articles by Sool Lee
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants
Highlights • MPRA functionally validates schizophrenia GWAS variants for differential allelic activity • An accessibility-by-contact model linked these variants to predicted gene expression • These genes include transcription factors, which can have broad gene expression impact Summary Genome-wide association studies (GWASs) have successfully identified 145 genomic regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging to discern causal variants.
Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits | Molecular Psychiatry
Abstract Cigarette smoking and alcohol use are among the most prevalent substances used worldwide and account for a substantial proportion of preventable morbidity and mortality, underscoring the public health significance of understanding their etiology. Genome-wide association studies (GWAS) have successfully identified genetic variants associated with cigarette smoking and alcohol use traits.
Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains
Chronic obstructive pulmonary disease Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains http://orcid.org/0000-0003-0334-4039Auyon J Ghosh1,2, http://orcid.org/0000-0001-6399-0249Aabida Saferali1, Sool Lee1, Robert Chase1, Matthew Moll1,2, Jarrett Morrow1, Jeong Yun1,2, Peter J Castaldi1, http://orcid.org/0000-0002-1342-4334Craig P Hersh1,2 1 Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA 2 Division of...
Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains
Chronic obstructive pulmonary disease Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains http://orcid.org/0000-0003-0334-4039Auyon J Ghosh1,2, http://orcid.org/0000-0001-6399-0249Aabida Saferali1, Sool Lee1, Robert Chase1, Matthew Moll1,2, Jarrett Morrow1, Jeong Yun1,2, Peter J Castaldi1, http://orcid.org/0000-0002-1342-4334Craig P Hersh1,2 1Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA 2Division of Pulmonary...
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