Soongweon Hong

Abstract The kidney epithelium's pivotal role in molecular filtration, metabolism, and excretion highlights the crucial importance of understanding kidney physiology in drug development. However, our knowledge is largely derived from non-human or non-physiological models, potentially limiting its applicability to humans.

Abstract Kidney organoids, replicating human development, pathology, and drug responses, are a promising model for advancing bioscience and pharmaceutical innovation. However, reproducibility, accuracy, and quantification challenges hinder their broader utility for advanced biological and pharmaceutical applications.

Abstract Understanding the development and pathogenesis of the human midbrain is critical for developing diagnostics and therapeutics for incurable neurological disorders including Parkinson's disease (PD). While organoid models are introduced to delineate midbrain-related pathogenesis based on experimental flexibility, there is currently a lack of tools with high fidelity for tracing the long-term dynamics of intact brain networks- an essential portrait of physiological states.