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Abstractand is toxic to colonic epith Epidemiological data reveal an association between obesity and inflammatory bowel disease (IBD). Furthermore, animal models demonstrate that maternal high-fat diet (HFD) and maternal obesity increase susceptibility to IBD in offspring.
Highlights • The expanding microbiota at weaning induces a vigorous immune reaction • The weaning reaction occurs during a specific time window • The weaning reaction prevents susceptibility to inflammatory pathologies in the adult • Microbiota-induced Treg cells are required for a protective weaning reaction Summary Microbes colonize all body surfaces at birth and participate in the development of the immune system.
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